On December 29, 2025, the Ministry of Ecology and Environment and the National Administration of Disease Control and Prevention jointly issued the List of Priority Controlled Chemicals (Third Batch), which includes 23 types of chemical substances such as 1,1,2,2-tetrachloroethane and bisphenol A. The screening and evaluation for this batch of the List primarily focused on high-hazard chemicals exhibiting persistence, bioaccumulation, as well as chronic aquatic toxicity category 1, carcinogenicity category 1 or 2, mutagenicity category 1 or 2, reproductive toxicity category 1 or 2, specific target organ toxicity—repeated exposure category 1, and endocrine-disrupting properties. Particular emphasis was placed on chemicals already subject to stringent controls under domestic industrial and import-export policies, as well as international environmental conventions. Concurrently, by integrating data from the national statistical survey on environmental information of chemical substances, environmental monitoring, and literature research, the potential environmental exposure scenarios across different stages of the chemical substances' life cycles were analyzed to assess their exposure potential.

The List includes 23 types of chemical substances, encompassing carcinogens such as 1,1,2,2-tetrachloroethane and tris(2,3-dibromopropyl) phosphate, endocrine disruptors such as bisphenol A and di(2-ethylhexyl) phthalate, and persistent organic pollutants like long-chain perfluorocarboxylic acids, their salts, and related compounds, which fall under the category of per- and polyfluoroalkyl substances (PFAS). These substances are involved in industries or sectors including petrochemicals, plastics, rubber, pharmaceuticals, textiles, dyes, coatings, pesticides, leather, and electroplating.

Currently, the management of chemical substances listed in the List of Priority Controlled Chemicals is primarily carried out in accordance with relevant requirements, including conducting environmental impact assessments for construction projects, implementing pollutant discharge permits, and enforcing soil and groundwater pollution prevention and control measures. An official from the Solid Waste and Chemicals Department of the Ministry of Ecology and Environment stated that relevant enterprises should fully recognize the potential environmental and health risks posed by the chemical substances in the List. They are encouraged to proactively adopt measures such as upgrading and transforming production processes, strengthening the treatment of wastewater, waste gas, and solid waste ("three wastes"), enhancing environmental emission controls, and actively researching, developing, and promoting the application of environmentally friendly alternatives to minimize the environmental risks associated with these chemical substances.