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Why do semiconductor fabs use isopropanol instead of ethanol for wafer cleaning?

Yuki Tanaka
Published on 2026-08-04

Why do semiconductor fabs use isopropanol instead of ethanol for wafer cleaning?
Wafer fabs prohibit ethanol as a primary cleaning agent for several reasons. Electronic-grade IPA reaches SEMI G5 purity of 99.9999% or higher, while ethanol cannot be easily dehydrated from its azeotrope and typically remains at reagent grade. IPA's moderate evaporation rate allows uniform drying without water marks, and it forms an azeotrope with deionized water suitable for Marangoni drying. Its slightly lower polarity than ethanol gives better compatibility with organic solvents like NMP and acetone, improving photoresist residue removal. IPA also has lower surface tension, leaving fewer spots after evaporation, making it the standard choice across wafer cleaning, etching, and equipment maintenance processes.

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  • Daniel Foster 2026-08-05 20:39
    Beyond purity, safety matters. IPA can form explosive peroxides, especially in clear glass bottles exposed to light — one case produced TATP after 12 years of storage. Fabs should store IPA in opaque containers, monitor peroxide levels, and avoid distillation of aged material. This is a hidden cost buyers often overlook when switching grades.
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