List of Regulated Chemicals for the Manufacture of Controlled Substances (as of November 25, 2024)
| No. | Regulated Chemical (English) | Chinese Name | List | DEA Code | Legal Authority | Effective Date |
|---|---|---|---|---|---|---|
| 1 | 1-BOC-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) and its salts (Prior to 11/9/2022, 1-BOC-4-AP was a list I chemical as a carbamate of 4-AP with an effective date of 05/15/2020) | 1-BOC-4-AP（4-(苯氨基)哌啶-1-甲酸叔丁酯）及其盐类（2022年11月9日前，1-BOC-4-AP作为4-AP的氨基甲酸酯，自2020年5月15日起列为List I化学品） | I | 8336 | 87 FR 67550 | 2022-11-09 |
| 2 | 1-BOC-4-PIPERIDONE (tert-butyl 4-oxopiperidine-1-carboxylate) and its salts (Prior to 10/2/2025, 1-BOC-4-PIPERIDONE was a list I chemical as a carbamate of 4-piperidone with an effective date of 05/12/2023) | 1-BOC-4-哌啶酮（4-氧代哌啶-1-甲酸叔丁酯）及其盐类（2025年10月2日前，1-BOC-4-哌啶酮作为4-哌啶酮的氨基甲酸酯，自2023年5月12日起列为List I化学品） | I | 8331 | 90 FR 47563 | 2025-10-02 |
| 3 | 4-ANILINOPIPERIDINE (N-phenylpiperidin-4-amine; N phenyl-4-piperidinamine; 4-AP) including its amides, its carbamates, its halides^, and its salts and any combination thereof, whenever the existence of such is possible. ^Halides designation specifically has an effective date of 11/30/2023 from a modification of the 4-anilinopiperidine listing. (See 88 FR 74352) | 4-苯胺基哌啶（N-苯基哌啶-4-胺；4-AP），包括其酰胺、氨基甲酸酯、卤化物^及其盐类，以及上述物质的任意组合（只要存在可能）。^卤化物类别自2023年11月30日起生效（见88 FR 74352） | I | 8335 | 85 FR 20822 | 2020-05-15 |
| 4 | 4-PIPERIDONE (piperidin-4-one) including its acetals, its amides, its carbamates, its salts, and salts of its acetals, its amides, and its carbamates, and any combination thereof, whenever the existence of such is possible | 4-哌啶酮（哌啶-4-酮），包括其缩醛、酰胺、氨基甲酸酯、盐类，以及上述衍生物的盐类和任意组合（只要存在可能） | I | 8330 | 88 FR 21902 | 2023-05-12 |
| 5 | ACETIC ANHYDRIDE | 乙酸酐 | II | 8519 | Pub. L. 100-690 | 1989-03-18 |
| 6 | ACETONE | 丙酮 | II | 6532 | Pub. L. 100-690 | 1989-03-18 |
| 7 | N-ACETYLANTHRANILIC ACID, salts & esters | N-乙酰邻氨基苯甲酸及其盐类与酯类 | I | 8522 | Pub. L. 100-690 | 1989-03-18 |
| 8 | ANTHRANILIC ACID, salts & esters | 邻氨基苯甲酸及其盐类与酯类 | I | 8530 | Pub. L. 100-690 | 1989-03-18 |
| 9 | APAA (Alpha-phenylacetoacetamide) and its optical isomers (Effective 06/09/2021) | α-苯基乙酰乙酰胺（APAA）及其光学异构体（2021年6月9日生效） | I | 8515 | 86 FR 24703 | 2021-06-09 |
| 10 | APAAN (Alpha-phenylacetoacetonitrile), salts, optical isomers, salts of optical isomers | α-苯基乙酰乙腈（APAAN）、其盐类、光学异构体及光学异构体的盐类 | I | 8512 | 82 FR 32457 | 2017-08-14 |
| 11 | BENZALDEHYDE | 苯甲醛 | I | 8256 | Pub. L. 103-200 | 1994-04-17 |
| 12 | BENZYL CHLORIDE | 氯化苄 | II | 8570 | Pub. L. 100-690 | 1989-03-18 |
| 13 | BENZYL CYANIDE | 苯乙腈 | I | 8735 | Pub. L. 100-690 | 1989-03-18 |
| 14 | BENZYLFENTANYL (N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide), including its salts. | 苄基芬太尼（N-(1-苄基哌啶-4-基)-N-苯基丙酰胺）及其盐类 | I | 8334 | 85 FR 20822 | 2020-05-15 |
| 15 | gamma-BUTYROLACTONE | γ-丁内酯 | I | 2011 | Pub. L. 106-172 | 2000-02-18 |
| 16 | EPHEDRINE, salts, optical isomers, & salts of optical isomers | 麻黄碱、其盐类、光学异构体及光学异构体的盐类 | I | 8113 | Pub. L. 100-690 | 1989-03-18 |
| 17 | EPHEDRINE - remove exemption for OTC single entity drug product | 麻黄碱—取消非处方单方药品豁免 | I | 8113 | Pub. L. 103-200 | 1994-04-17 |
| 18 | EPHEDRINE - remove exemption for OTC combination products and establish a 24 g retail threshold. Threshold remains zero for single entity products. Mail order report requirements imposed. For more info, see 21 CFR Parts 1309, 1310, 1313 | 麻黄碱—取消非处方复方产品豁免，设定24克零售阈值（单方产品仍为零阈值），并实施邮购报告要求（详见21 CFR第1309、1310、1313部分） | I | 8113 | Pub. L. 104-237 | 1996-10-03 |
| 19 | ERGONOVINE or ERGOMETRINE & salts | 麦角新碱（或称麦角代谢碱）及其盐类 | I | 8675 | Pub. L. 100-690 | 1989-03-18 |
| 20 | ERGOCRISTINE | 麦角克碱（cas 511-08-0） | I | 8612 | 76 FR 17778 | 2011-05-02 |
| 21 | ERGOTAMINE & salts | 麦角胺及其盐类 | I | 8676 | Pub. L. 100-690 | 1989-03-18 |
| 22 | ETHYLAMINE & salts | 乙胺及其盐类 | I | 8678 | Pub. L. 101-647 | 1991-02-27 |
| 23 | N-ETHYLEPHEDRINE - superseded by 1994 action | N-乙基麻黄碱—被1994年行动取代 | REMOVED | Pub. L. 101-647 | 1991-02-27 | |
| 24 | N-ETHYLEPHEDRINE | N-乙基麻黄碱 | REMOVED | Pub. L. 103-200 | 1994-04-17 | |
| 25 | ETHYL ETHER | 乙醚 | II | 6584 | Pub. L. 100-690 | 1989-03-18 |
| 26 | N-ETHYLPSEUDOEPHEDRINE - superseded by 1994 action | N-乙基伪麻黄碱—被1994年行动取代 | REMOVED | Pub. L. 101-647 | 1991-02-27 | |
| 27 | N-ETHYLPSEUDOEPHEDRINE | N-乙基伪麻黄碱 | REMOVED | Pub. L. 103-200 | 1994-04-17 | |
| 28 | HYDROCHLORIC ACID (including anhydrous hydrogen chloride) | 盐酸（包括无水氯化氢） | II | 6545 | 57 FR 43614 | 1992-10-22 |
| 29 | HYDROCHLORIC GAS (anhydrous hydrogen chloride) | 氯化氢气体（无水氯化氢） | II | 6545 | Pub. L. 104-237 | 1996-10-03 |
| 30 | HYDRIODIC ACID - superseded by 1990 action | 氢碘酸—被1990年行动取代 | II | 6695 | Pub. L. 100-690 | 1989-03-18 |
| 31 | HYDRIODIC ACID | 氢碘酸 | I | 6695 | Pub. L. 101-647 | 1991-02-27 |
| 32 | HYPOPHOSPHOROUS ACID, salts (Including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite, and sodium hypophosphite) | 次磷酸及其盐类（包括次磷酸铵、次磷酸钙、次磷酸铁、次磷酸钾、次磷酸锰、次磷酸镁和次磷酸钠） | I | 6797 | 66 FR 52670 | 2001-11-16 |
| 33 | IODINE - superseded by 2007 action | 碘—被2007年行动取代 | II | 6699 | Pub. L. 104-237 | 1996-10-03 |
| 34 | IODINE | 碘 | I | 6699 | 72 FR 35920 | 2007-08-01 |
| 35 | ISOSAFROLE | 异黄樟素 | I | 8704 | Pub. L. 101-647 | 1991-02-27 |
| 36 | D-LYSERGIC ACID, salts, optical isomers, & salts of optical isomers - superseded | D-麦角酸、其盐类、光学异构体及光学异构体的盐类—已被取代 | REMOVED | 7300 | Pub. L. 101-647 | 1991-02-27 |
| 37 | D-LYSERGIC ACID, salts, optical isomers, & salts of optical isomers* | D-麦角酸、其盐类、光学异构体及光学异构体的盐类* | REMOVED | 7300 | Pub. L. 103-200 | 1994-04-17 |
| 38 | METHYLAMINE and salts | 甲胺及其盐类 | I | 8520 | Pub. L. 101-647 | 1991-02-27 |
| 39 | METHYL ALPHA-PHENYLACETOACETATE (MAPA) | 甲基-α-苯基乙酰乙酸酯（MAPA） | I | 8795 | 86 FR 64362 | 2021-12-20 |
| 40 | 3,4-METHYLENEDIOXYPHENYL-2-PROPANONE | 3,4-亚甲基二氧苯基-2-丙酮 | I | 8502 | Pub. L. 100-690 | 1989-03-18 |
| 41 | N-METHYLEPHEDRINE, salts, optical isomers, & salts of optical isomers | N-甲基麻黄碱、其盐类、光学异构体及光学异构体的盐类 | I | 8115 | Pub. L. 101-647 | 1991-02-27 |
| 42 | METHYL ETHYL KETONE (MEK) or 2-BUTANONE | 甲基乙基酮（MEK）或2-丁酮 | II | 6714 | Pub. L. 100-690 | 1989-03-18 |
| 43 | METHYL ISOBUTYL KETONE (MIBK) | 甲基异丁基酮（MIBK） | II | 6715 | 60 FR 19509 | 1995-05-19 |
| 44 | N-METHYLPSEUDOEPHEDRINE, salts, optical isomers, salts of optical isomers | N-甲基伪麻黄碱、其盐类、光学异构体及光学异构体的盐类 | I | 8119 | Pub. L. 101-647 | 1991-02-27 |
| 45 | NITROETHANE | 硝基乙烷 | I | 6724 | Pub. L. 103-200 | 1994-04-17 |
| 46 | NORPSEUDOEPHEDRINE, salts, optical isomers, & salts of optical isomers | 去甲伪麻黄碱、其盐类、光学异构体及光学异构体的盐类 | I | 8317 | Pub. L. 100-690 | 1989-03-18 |
| 47 | N-PHENETHYL-4-PIPERIDONE (NPP) | N-苯乙基-4-哌啶酮（NPP） | I | 8332 | 73 FR 43355 | 2007-04-23 |
| 48 | PHENYLACETIC ACID, esters, and salts | 苯乙酸及其酯类和盐类 | I | 8791 | Pub. L. 100-690 | 1989-03-18 |
| 49 | PHENYLPROPANOLAMINE, salts, optical isomers, & salts of optical isomers | 苯丙醇胺、其盐类、光学异构体及光学异构体的盐类 | I | 1225 | Pub. L. 100-690 | 1989-03-18 |
| 50 | PHENYLPROPANOLAMINE - remove exemption for certain OTC transactions. Retail threshold of 24 g established for products not distributed in blister packs. Mail order report requirements imposed. For more info, see 21 CFR Parts 1309, 1310, and 1313. | 苯丙醇胺—取消部分非处方交易豁免，对非泡罩包装产品设24克零售阈值，并实施邮购报告要求（详见21 CFR第1309、1310、1313部分） | I | 1225 | Pub. L. 104-237 | 1997-10-03 |
| 51 | PIPERIDINE and salts | 哌啶及其盐类 | I | 2704 | Pub. L. 100-690 | 1989-03-18 |
| 52 | PIPERONAL | 胡椒醛 | I | 8750 | Pub. L. 101-647 | 1991-02-27 |
| 53 | PMK GLYCIDATE (3,4-MDP-2-P METHYL GLYCIDATE) and its optical and geometric isomers (Effective 06/09/2021) | PMK缩水甘油酸酯（3,4-亚甲基二氧苯基-2-丙酮甲基缩水甘油酸酯）及其光学与几何异构体（2021年6月9日生效） | I | 8535 | 86 FR 24703 | 2021-06-09 |
| 54 | PMK GLYCIDIC ACID (3,4-MDP-2-P METHYL GLYCIDIC ACID) and its salts, optical and geometric isomers, and salts of isomers (Effective 06/09/2021) | PMK缩水甘油酸（3,4-亚甲基二氧苯基-2-丙酮甲基缩水甘油酸）及其盐类、光学与几何异构体，以及异构体的盐类（2021年6月9日生效） | I | 8525 | 86 FR 24703 | 2021-06-09 |
| 55 | POTASSIUM PERMANGANATE | 高锰酸钾 | II | 6579 | Pub. L. 100-690 | 1989-03-18 |
| 56 | PROPIONIC ANHYDRIDE | 丙酸酐 | I | 8328 | Pub. L. 101-647 | 1991-02-27 |
| 57 | PSEUDOEPHEDRINE, salts, optical isomers, & salts of optical isomers | 伪麻黄碱、其盐类、光学异构体及光学异构体的盐类 | I | 8112 | Pub. L. 100-690 | 1989-03-18 |
| 58 | PSEUDOEPHEDRINE - remove exemption for certain OTC transactions. Retail threshold of 24 g established for products not distributed in blister packs. Mail order report requirements imposed. For more info, see 21 CFR Parts 1309, 1310, and 1313. | 伪麻黄碱—取消部分非处方交易豁免，对非泡罩包装产品设24克零售阈值，并实施邮购报告要求（详见21 CFR第1309、1310、1313部分） | I | 8112 | Pub. L. 104-237 | 1997-10-03 |
| 59 | RED PHOSPHORUS | 红磷 | I | 6795 | 66 FR 52670 | 2001-11-16 |
| 60 | SAFRO |
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