Ampicillin Price Chart & Market Analysis 2026

Ampicillin Price Information

Newest Price 13,937.5

Price Date 20210323

Day's Change +774.5

Day's Range 13,937.5 - 14,712

Month's Change 0

Month's Range 0 - 0

Year's Change 0

Year's Range 0 - 0

Opinions

How does ampicillin's beta-lactamase instability affect its industrial quality control and downstream demand?

Quality control is becoming a differentiator. Buyers sourcing ampicillin for human injectable use should verify beta-lactamase stability data and impurity profiles, not just assay content. The shift toward combination products like ampicillin-sulbactam may erode plain ampicillin demand growth, so contract terms should account for potential oversupply in standard grades.

What is the outlook for China's ampicillin production capacity amid ongoing industry consolidation?

The enzyme versus chemical synthesis cost gap is narrowing as enzyme technology matures. Buyers should qualify multiple suppliers across both routes to maintain negotiating leverage. Also note that environmental compliance costs are rising for older chemical synthesis plants, which may accelerate closures and benefit enzyme-based producers with modern facilities.

What is driving the recent price divergence between ampicillin and ampicillin sodium in China?

The year-on-year drop in ampicillin sodium is notable. Watch capacity migration: Shandong Lukang's relocation project keeps ampicillin sodium at only 20 t/a while adding piperacillin and mezlocillin. This signals producers are reallocating sterile capacity toward higher-value penicillins, which could tighten ampicillin sodium supply in 2025-2026.

Overview

Ampicillin (氨苄西林, CAS 69-53-4) is a white to off-white crystalline powder with a melting point of 198–200°C (dec.) and moderate water solubility. It is a semi-synthetic broad-spectrum penicillin antibiotic active against both Gram-positive and Gram-negative bacteria.

Pharmaceuticals: treats a range of bacterial infections; a classic β-lactam antibiotic that inhibits bacterial cell wall synthesis by interfering with penicillin-binding proteins.
Laboratory/molecular biology: commonly used as a selection agent in LB media and plates for plasmids carrying the bla resistance gene.
Veterinary: used in animal health applications, including enzyme-processed penicillin derivatives for veterinary APIs.

China's production landscape centers on semi-synthetic penicillin intermediates such as 6-APA, with the industry consolidating amid stricter environmental and industrial policies. Ampicillin is available in oral and injectable forms, and the market is subject to regulatory constraints on new penicillin production capacity.

Key domestic producers:
North China Pharmaceutical – major penicillin and semi-synthetic antibiotic producer.
Kelun Pharmaceutical – active in antibiotic intermediates and finished dosage forms.
Anglikang Pharmaceutical – upstream investment in antibiotic side-chain intermediates.

Properties

Name

Ampicillin

(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-[2alpha, 5alpha, 6beta(S*)]]-

6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid

6-[D(-)-alpha-aminophenylacetamido]penicillanic acid

CAS Number

69-53-4

EINECS No.

200-709-7

Risk Codes

S22;S26;S36/37;S45;S53

Safety Description

R36/37/38;R42/43;R61

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Ampicillin Price Information

Opinions

How does ampicillin's beta-lactamase instability affect its industrial quality control and downstream demand?

What is the outlook for China's ampicillin production capacity amid ongoing industry consolidation?

What is driving the recent price divergence between ampicillin and ampicillin sodium in China?

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